Investigation of the Quantity of Exhaled Aerosols Released into the Environment during Nebulisation
McGrath JA, O’Sullivan A, Bennett G, et al. Pharmaceutics.
In this month's Clinical Spotlight: McGrath et al. found that a vibrating mesh nebulizer used with a mouthpiece and filter minimized the risk of exhaled medical aerosol emissions compared to baseline. (McGrath et al. 2019)
Nasal High-Flow Bronchodilator Nebulization: A Randomized Cross-Over Study
Reminiac F, Vecellio L, Bodet-Contentin L, et al. Ann Intensive Care. 2018 Dec 20;8(1):128
Albuterol vibrating mesh nebulization within a nasal high-flow circuit induces similar bronchodilation to standard facial mask jet nebulization.
Comparison of bronchodilator administration with vibrating mesh nebulizer and standard jet nebulizer in the emergency department
Dunne RB and Shortt S. Am J Emerg Med. 2018 Apr;36(4):641-646.
In this month's Clinical Spotlight: Dunne et al. showed that 85% of patients treated with a vibrating mesh nebulizer achieved symptom control with a single bronchodilator dose. (Dunne & Shorrt)
Clinical efficacy of vibrating mesh and jet nebulizers with different interfaces in pediatric subjects with asthma
Moody GB, Luckett PM, Shockley CM, et al.
In this month's Clinical Spotlight: Moody et al. studies the clinical outcomes following bronchodilator delivery via the Aerogen® Ultra Versus a jet nebuliser in children presenting to the Emergency Department with acute moderate-to-severe asthma (Moody et al. 2020)
Impact of Gas Flow and Humidity on Trans-Nasal Aerosol Deposition via Nasal Cannula in Adults: A Randomized Cross-Over Study
Alcoforado L, Ari A, Barcelar JM, et al. Pharmaceutics. 2019 Jul 7;11(7):320.
A lung dose of 17.2 % is achievable at a flow rate of 10 L/min. Lower flow rates correlate with higher lung drug deposition.
Aerosol delivery with two ventilation modes during mechanical ventilation: A randomized study
Dugernier J, Reychler G, Wittebole X, et al. Ann Intensive Care. 2016 Dec;6(1):73
In this months clinical spotlight: Dugernier et al. compares lung deposition of a radiolabeled aerosol generated with a vibrating-mesh nebulizer during invasive mechanical ventilation, with two modes: pressure support
SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study
Dugernier J, Hesse M, Vanbever R, et al. Pharm Res. 2017 Feb;34(2):290-300.
Lung dose was six times higher with the Ultra (34.1%) vs Jet Neb (5.2%)
Radioaerosol Pulmonary Deposition Using Mesh and Jet Nebulizers During Noninvasive Ventilation in Healthy Subjects
Galindo-Filho VC, Ramos ME, Rattes CS, et al. Respir Care. 2015 Sep;60(9):1238-46.
In this month's Clinical Spotlight: An imaging study by Galindo-Filho et al. reported significantly greater aerosol delivery to the lungs with vibrating mesh during non-invasive ventilation as compared with a jet nebulizer, in healthy adults. (Galindo-Filho et al.)
Dose Response to Transnasal Pulmonary Administration of Bronchodilator Aerosols via Nasal High-Flow Therapy in Adults with Stable Chronic Obstructive Pulmonary Disease and Asthma
Li J, Zhao M, Hadeer M, et al. Respiration. 2019;98(5):401-409
In this month's Clinical Spotlight: Li et al. showed that bronchodilator delivery via vibrating mesh inline during high flow nasal cannula results in a positive bronchodilator response in patients with stable asthma and COPD.(Li et al.)
Worldwide Clinical Practice of High-Flow Nasal Cannula and Concomitant Aerosol Therapy in the Adult ICU Setting
Li J, Tu M, Yang L, et al. Respir Care. 2021 Sep;66(9):1416-1424
In this months clinical spotlight: Li et al. aims to provide insight into the practical implementation of HFNC and how to provide aerosol delivery during HFNC therapy in adult patients.
Comparison of Vibrating Mesh and Jet Nebulizers During Noninvasive Ventilation in Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Avdeev SN, Nuralieva GS, Soe AK, et al. J Aerosol Med Pulm Drug Deliv. 2021 Dec;34(6):358-365.
In this month's Clinical Spotlight: Avdeev and colleagues showed that patients on non-invasive ventilation treated with albuterol delivered by vibrating mesh displayed improved lung function and symptom scores, as compared with a jet nebulizer. (Avdeev et al.)
Bronchodilator Delivery via High-Flow Nasal Cannula: A Randomized Controlled Trial to Compare the Effects of Gas Flows
Li J, Chen Y, Ehrmann S, et al. Pharmaceutics. 2021 Oct 11;13(10):1655
In this month's Clinical Spotlight, Li et al investigated the effect of high-flow on response to aerosolised bronchodilator therapy delivered using the Aerogen Solo in patients with asthma or COPD. (Li et al.)
